Intracranial Calcification

Familial idiopathic basal ganglia calcification (FIBGC) is a rare neurodegenerative disease that presents with an array of neuropsychiatric disturbances and movement disorders. Adolescents and young adults are most commonly affected, with symptom onset typically in the third to fifth decade of life; however, there have been some cases reported in older adults. The syndrome is rarely encountered in older adults because FIBGC is an autosomal dominant disorder with a 95% penetrance by age 50 years or older.In this recent article, Sheta and Angi present the case of a septuagenarian who presented with worsening confusion and cognition over 2 months. A diagnosis of FIBGC was made without a known family history of the condition based on the patient’s clinical symptoms of cognitive impairment and dysarthria and by ruling out other potential causes of intracranial calcification. Read the full case report here>>

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